Article
NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control.
Cell - 22 Feb 2018
Böttcher Jan P, Bonavita Eduardo, Chakravarty Probir, Blees Hanna, Cabeza-Cabrerizo Mar, Sammicheli Stefano, Rogers Neil C, Sahai Erik, Zelenay Santiago, Reis e Sousa Caetano
Abstract excerpt
Conventional type 1 dendritic cells (cDC1) are critical for antitumor immunity, and their abundance within tumors is associated with immune-mediated rejection and the success of immunotherapy. Here, we show that cDC1 accumulation in mouse tumors often depends on natural killer (NK) cells that produce the cDC1 chemoattractants CCL5 and XCL1. Similarly, in human cancers, intratumoral CCL5, XCL1, and XCL2...
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