CD4+ helper T cells endow cDC1 with cancer-impeding functions in the human tumor micro-environment

Abstract excerpt

Abstract Despite their low abundance in the tumor microenvironment (TME), classical type 1 dendritic cells (cDC1) play a pivotal role in anti-cancer immunity, and their abundance positively correlates with patient survival. However, their interaction with CD4 + T-cells to potentially enable the cytotoxic T lymphocyte (CTL) response has not been elucidated. Here we show that contact with activated CD4 + T-cells...

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