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Article

Differential effects of SORL1 deficiency on the endo-lysosomal network in human neurons and microglia

18 Feb 2024

Abstract excerpt

protein SORL1/SORLA is an endosomal receptor that interacts with the multi-protein sorting complex retromer to traffic various cargo through the endo-lysosomal network (ELN). Impairments in endo-lysosomal trafficking are an early cellular symptom in AD and a novel therapeutic target. However, the cell types of the central nervous system are diverse and use the ELN differently. If this pathway is to be effectively...

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PMID: 38368935
DOI: 10.1098/rstb.2022.0389

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