Investigating the Endo-Lysosomal System in Major Neurocognitive Disorders Due to Alzheimer's Disease, Frontotemporal Lobar Degeneration and Lewy Body Disease: Evidence for SORL1 as a Cross-Disease Gene.

doi:10.3390/ijms222413633

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Investigating the Endo-Lysosomal System in Major Neurocognitive Disorders Due to Alzheimer's Disease, Frontotemporal Lobar Degeneration and Lewy Body Disease: Evidence for SORL1 as a Cross-Disease Gene.

International journal of molecular sciences - 20 Dec 2021

Benussi Luisa, Longobardi Antonio, Kocoglu Cemile, Carrara Matteo, Bellini Sonia, Ferrari Clarissa, Nicsanu Roland, Saraceno Claudia, Bonvicini Cristian, Fostinelli Silvia, Zanardini Roberta, Catania Marcella, Moisse Matthieu, Van Damme Philip, Di Fede Giuseppe, Binetti Giuliano, Van Broeckhoven Christine, van der Zee Julie, Ghidoni Roberta

Abstract excerpt

Dysfunctions in the endo-lysosomal system have been hypothesized to underlie neurodegeneration in major neurocognitive disorders due to Alzheimer's disease (AD), Frontotemporal Lobar Degeneration (FTLD), and Lewy body disease (DLB). The aim of this study is to investigate whether these diseases share genetic variability in the endo-lysosomal pathway. In AD, DLB, and FTLD patients and in controls (948 subjects),...

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PMID: 34948429
DOI: 10.3390/ijms222413633
PMCID: PMC8704369

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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