Article
Human SH2B1 mutations are associated with maladaptive behaviors and obesity.
The Journal of clinical investigation - 1 Dec 2012
Doche Michael E, Bochukova Elena G, Su Hsiao-Wen, Pearce Laura R, Keogh Julia M, Henning Elana, Cline Joel M, Saeed Sadia, Dale Anne, Cheetham Tim, Barroso Inês, Argetsinger Lawrence S, O'Rahilly Stephen, Rui Liangyou, Carter-Su Christin, Farooqi I Sadaf
Abstract excerpt
Src homology 2 B adapter protein 1 (SH2B1) modulates signaling by a variety of ligands that bind to receptor tyrosine kinases or JAK-associated cytokine receptors, including leptin, insulin, growth hormone (GH), and nerve growth factor (NGF). Targeted deletion of Sh2b1 in mice results in increased food intake, obesity, and insulin resistance, with an intermediate phenotype seen in heterozygous null mice on a...
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