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Article

Rational Engraftment of Quaternary-Interactive Acidic Loops for Anti-HIV-1 Antibody Improvement.

Journal of virology - 24 May 2021

Liu Qingbo, Zhang Peng, Miao Huiyi, Lin Yin, Kwon Young Do, Kwong Peter D, Rikhtegaran-Tehrani Zahra, Seaman Michael S, DeVico Anthony L, Sajadi Mohammad M, Lusso Paolo

Abstract excerpt

Broadly neutralizing antibodies (bNAbs) are the focus of increasing interest for human immunodeficiency virus type 1 (HIV-1) prevention and treatment. Although several bNAbs are already under clinical evaluation, the development of antibodies with even greater potency and breadth remains a priority. Recently, we reported a novel strategy for improving bNAbs against the CD4-binding site (CD4bs) of gp120 by...

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Share to Binding Sites, Antibody
Share to Broadly Neutralizing Antibodies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33827946
DOI: 10.1128/JVI.00159-21
PMCID: PMC8315909

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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