Article

A Novel SCA3 Knock-in Mouse Model Mimics the Human SCA3 Disease Phenotype Including Neuropathological, Behavioral, and Transcriptional Abnormalities Especially in Oligodendrocytes

2021-06-29

Abstract excerpt

<title>Abstract</title> <p>Spinocerebellar ataxia type 3 is the most common autosomal dominant inherited ataxia worldwide, caused by a CAG repeat expansion in the <italic>Ataxin-3</italic> gene resulting in a polyQ-expansion in the corresponding protein. The disease is characterized by neuropathological, phenotypical, and specific transcriptional changes in affected brain regions. So far, there is no mouse model...

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Literature Corpus work: ea4440e8-724e-5459-953a-e60e8d27512d
DOI: 10.21203/rs.3.rs-634343/v1

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