Article

Delineating regional vulnerability in the neurodegenerative disease SCA1 using a conditional mutant ATXN1 mouse

2023-02-08

Abstract excerpt

<h4>ABSTRACT</h4> Spinocerebellar ataxia type 1 (SCA1) is a fatal neurodegenerative disease caused by an expanded polyglutamine tract in the widely expressed ATXN1 protein. To elucidate anatomical regions and cell types that underlie mutant ATXN1-induced disease phenotypes, we developed a floxed conditional knockout mouse model ( f-ATXN1 146Q/2Q ) having mouse Atxn1 coding exons replaced by human exons encodin...

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Literature Corpus work: 4688a28c-4834-56a3-be6d-053313e5e70b
DOI: 10.1101/2023.02.08.527710

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