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Article

Epigenetic control of ataxin‐1 in multiple sclerosis

28 Jul 2022

Abstract excerpt

OBJECTIVE: ATXN1 encodes the polyglutamine protein ataxin-1, which we have demonstrated exerting an immunomodulatory function in the context of central nervous system (CNS) autoimmunity, in addition to its classical role in the neurodegenerative disorder spinocerebellar ataxia type 1 (SCA1). In this study, we dissected the contribution of DNA methylation to the regulation of ATXN1 in multiple sclerosis (MS)....

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PMID: 35903875
DOI: 10.1002/acn3.51618

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