Article

BRAFV600E-induced senescence drives Langerhans Cell Histiocytosis pathophysiology

2020-11-04

Abstract excerpt

Langerhans cell histiocytosis (LCH) is a potentially fatal condition characterized by granulomatous lesions with characteristic clonal mononuclear phagocytes (MNP) harboring activating somatic mutations in MAPK pathway genes, most notably BRAFV600E. We recently discovered that the BRAFV600E mutation can also affect multipotent hematopoietic progenitor cells (HPC) in multisystem LCH disease. How BRAFV600E mutation...

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Literature Corpus work: 792ab32d-a467-54ac-83df-9cef538afafe
DOI: 10.21203/rs.3.rs-98634/v1

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