Article

Loss of the lysosomal lipid flippase ATP10B leads to progressive dopaminergic neurodegeneration and Parkinsonian motor deficits

2024-07-13

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> ATP10B, a transmembrane lipid flippase located in late endosomes and lysosomes, facilitates the export of glucosylceramide and phosphatidylcholine by coupling this process to ATP hydrolysis. Recently, loss-of-function mutations in the ATP10B gene have been identified in Parkinson’s disease patients, pointing to ATP10B as a candidate genetic risk factor. Previous studies ha...

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Literature Corpus work: fd6cdd6a-9034-5b4b-afdd-764589ed3c74
DOI: 10.1101/2024.07.09.602700

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