Article

Nigral ATP13A2 depletion induces Parkinson's disease-related neurodegeneration in non-human primates

2024-01-22

Abstract excerpt

<title>Abstract</title> <p>Lysosomal impairment is strongly implicated in Parkinson's disease (PD). Among the several PD-linked genes, the <italic>ATP13A2</italic> gene, associated with the PARK9 locus, encodes a transmembrane lysosomal P5-type ATPase that acts as a lysosomal polyamine exporter. Mutations in the <italic>ATP13A2</italic> gene were primarily identified as the cause of Kufor-Rakeb syndrome (KRS), a...

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Literature Corpus work: 1fee62fb-fa76-5e89-a72c-b0652e72ab83
DOI: 10.21203/rs.3.rs-3845030/v1

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