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Article

ALS-associated FUS mutation reshapes the RNA and protein composition of stress granules.

Nucleic acids research - 27 Nov 2024

Mariani Davide, Setti Adriano, Castagnetti Francesco, Vitiello Erika, Stufera Mecarelli Lorenzo, Di Timoteo Gaia, Giuliani Andrea, D'Angelo Angelo, Santini Tiziana, Perego Eleonora, Zappone Sabrina, Liessi Nara, Armirotti Andrea, Vicidomini Giuseppe, Bozzoni Irene

Abstract excerpt

Stress granules (SG) are part of a cellular protection mechanism where untranslated messenger RNAs and RNA-binding proteins are stored upon conditions of cellular stress. Compositional variations due to qualitative or quantitative protein changes can disrupt their functionality and alter their structure. This is the case of different forms of amyotrophic lateral sclerosis (ALS) where a causative link has been...

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Share to Amyotrophic Lateral Sclerosis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39494508
DOI: 10.1093/nar/gkae942
PMCID: PMC11602144

Genes

FUS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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ALS-associated FUS mutation reshapes the RNA and protein composition of stress granules.PMID 39494508Read ↗

ALS-associated FUS mutation reshapes the RNA and protein composition of Stress GranulesSemantic proximity Read ↗

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