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Article

ALS-linked cytoplasmic FUS assemblies are compositionally different from physiological stress granules and sequester hnRNPA3, a novel modifier of FUS toxicity.

Neurobiology of disease - 1 Jan 2022

An Haiyan, Litscher Gioana, Watanabe Naruaki, Wei Wenbin, Hashimoto Tadafumi, Iwatsubo Takeshi, Buchman Vladimir L, Shelkovnikova Tatyana A

Abstract excerpt

Formation of cytoplasmic RNA-protein structures called stress granules (SGs) is a highly conserved cellular response to stress. Abnormal metabolism of SGs may contribute to the pathogenesis of (neuro)degenerative diseases such as amyotrophic lateral sclerosis (ALS). Many SG proteins are affected by mutations causative of these conditions, including fused in sarcoma (FUS). Mutant FUS variants have high affinity to...

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Identifiers

PMID: 34915152
DOI: 10.1016/j.nbd.2021.105585
PMCID: PMC8799889

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