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Transcriptomic phase transitions along the Alzheimer’s disease continuum using riemmaninan tensor model: a bifurcation-intermediate variance framework on the ROSMAP cohort

2026-05-29

Abstract excerpt

Alzheimer’s disease (AD) progression involves systemic network transitions. To capture these using ROSMAP bulk RNA-seq (n=624), we focused on the geometry of the covariance structure, performing a Riemannian (Log-Euclidean) analysis of stage-wise covariance matrices as points on the manifold of symmetric positive-definite (SPD) matrices. On the SPD manifold the three stages were non-collinear: geodesic distances w...

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Literature Corpus work
fd5faeb2-f9fe-5c42-a055-2f2524310b78
DOI
10.64898/2026.05.26.727786
Open publication

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Transcriptomic phase transitions along the Alzheimer’s disease continuum using riemmaninan tensor model: a bifurcation-intermediate variance framework on the ROSMAP cohortDOI 10.64898/2026.05.26.727786
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