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Article

The graded multidimensional geometry of phenotypic variation and progression in neurodegenerative syndromes.

Brain : a journal of neurology - 3 Feb 2025

Ramanan Siddharth, Akarca Danyal, Henderson Shalom K, Rouse Matthew A, Allinson Kieren, Patterson Karalyn, Rowe James B, Lambon Ralph Matthew A

Abstract excerpt

Clinical variants of Alzheimer's disease and frontotemporal lobar degeneration display a spectrum of cognitive-behavioural changes varying between individuals and over time. Understanding the landscape of these graded individual/group level longitudinal variations is critical for precise phenotyping; however, this remains challenging to model. Addressing this challenge, we leverage the National Alzheimer's...

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Identifiers

PMID: 39018014
DOI: 10.1093/brain/awae233
PMCID: PMC11788217

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