Article

Molecular estimation of neurodegeneration pseudotime in older brains

2019-06-28

Abstract excerpt

The temporal molecular changes that lead to disease onset and progression in Alzheimer’s disease are still unknown. Here we develop a temporal model for these unobserved molecular changes with a manifold learning method applied to RNA-Seq data collected from human postmortem brain samples collected within the ROS/MAP and Mayo Clinic RNA-Seq studies. We define an ordering across samples based on their similarity in...

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Literature Corpus work: e1a3bf13-a2d2-5f29-abec-87cf3f41b0ce
DOI: 10.1101/686824

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