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Article

Differentiation of human intestinal organoids with endogenous vascular endothelial cells

2020-03-15

Abstract excerpt

<h4>SUMMARY</h4> Human pluripotent stem cell (hPSC)-derived intestinal organoids (HIOs) generated using directed differentiation lack some cellular populations found in the native organ, including vasculature. Using single cell RNA sequencing (scRNAseq), we have identified a transient population of endothelial cells (ECs) present early in HIO differentiation that are lost over time in culture. Here, we have devel...

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Literature Corpus work
fd5f43c9-9b49-5f0b-af34-a0e28cba86a0
DOI
10.1101/2020.03.15.991950
Open publication

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Differentiation of human intestinal organoids with endogenous vascular endothelial cellsDOI 10.1101/2020.03.15.991950
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