Article

Deciphering Endothelial and Mesenchymal Organ Specification in Vascularized Lung and Intestinal Organoids

2024-02-07

Abstract excerpt

<h4>Summary</h4> To investigate the co-development of vasculature, mesenchyme, and epithelium crucial for organogenesis and the acquisition of organ-specific characteristics, we constructed a human pluripotent stem cell-derived organoid system comprising lung or intestinal epithelium surrounded by organotypic mesenchyme and vasculature. We demonstrated the pivotal role of co-differentiating mesoderm and endoderm...

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Literature Corpus work: 5c0819cb-e55b-535b-a9e0-66de7697ba47
DOI: 10.1101/2024.02.06.577460

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