Article

Latrophilin-2 mediates fluid shear stress mechanotransduction at endothelial junctions

2024-06-14

Abstract excerpt

Endothelial cell responses to fluid shear stress from blood flow are crucial for vascular development, function and disease. A complex of PECAM-1, VE-cadherin, VEGF receptors (VEGFRs) and PlexinD1 located at cell-cell junctions mediates many of these events. But available evidence suggests that another mechanosensor upstream of PECAM-1 initiates signaling. Hypothesizing that GPCR and Gα proteins may serve this rol...

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Literature Corpus work: 5b5b4d37-a602-59fc-8025-89980c2a9e3d
DOI: 10.1101/2024.06.13.598386

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