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A p53 Super-tumor Suppressor Reveals a Tumor Suppressive p53-Ptpn14-Yap Axis in Pancreatic Cancer.

Cancer cell - 9 Oct 2017

Mello Stephano S, Valente Liz J, Raj Nitin, Seoane Jose A, Flowers Brittany M, McClendon Jacob, Bieging-Rolett Kathryn T, Lee Jonghyeob, Ivanochko Danton, Kozak Margaret M, Chang Daniel T, Longacre Teri A, Koong Albert C, Arrowsmith Cheryl H, Kim Seung K, Vogel Hannes, Wood Laura D, Hruban Ralph H, Curtis Christina, Attardi Laura D

Abstract excerpt

The p53 transcription factor is a critical barrier to pancreatic cancer progression. To unravel mechanisms of p53-mediated tumor suppression, which have remained elusive, we analyzed pancreatic cancer development in mice expressing p53 transcriptional activation domain (TAD) mutants. Surprisingly, the p5353,54 TAD2 mutant behaves as a "super-tumor suppressor," with an enhanced capacity to both suppress pancreatic...

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Source

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Identifiers

PMID: 29017057
DOI: 10.1016/j.ccell.2017.09.007
PMCID: PMC5659188

Genes

PTPN14

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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