Poly-(A)-binding protein cytoplasmic 1 gene regulates cell proliferation via TP53 R273H hotspot activation in Japanese patients with common cancer types

Abstract excerpt

<title>Abstract</title> <p>Background Mutations in <italic>TP53</italic> occur in approximately half of all common cancer types, and play a critical role in tumor progression and metastasis. However, because mutant <italic>TP53</italic> can result in both loss and gain of function in cells, complicating the development of drugs that directly target <italic>TP53</italic>. We screened for genes whose expression is...

Topics

Open a Topic to create a Post that cites this publication.

• Apoptosis
• Cancer-related Molecular Pathways
• Cell Proliferation
• Cisplatin
• Drug Resistance, Neoplasm
• Molecular Dynamics Simulation
• Neoplasm Invasiveness
• Tumor Suppressor Protein p53

Identifiers and source

Literature Corpus work

fd3c6227-ac8b-54d8-9de4-a8b65430e734

DOI

10.21203/rs.3.rs-7115778/v1