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Article

Integrative assessment of CIP2A overexpression and mutational effects in human malignancies identifies possible deleterious variants.

Computers in biology and medicine - 1 Dec 2021

Tarek Mohammad M, Yahia Ahmed, El-Nakib Mostafa M, Elhefnawi Mahmoud

Abstract excerpt

KIAA1524 is the gene encoding the human cancerous inhibitor of PP2A (CIP2A) protein which is regarded as a novel target for cancer therapy. It is overexpressed in 65%-90% of tissues in almost all studied human cancers. CIP2A expression correlates with cancer progression, disease aggressivity in lung cancer besides poor survival and resistance to chemotherapy in breast cancer. Herein, a pan-cancer analysis of...

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PMID: 34739970
DOI: 10.1016/j.compbiomed.2021.104986

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