Article
Clinical significance of PICT1 in patients of hepatocellular carcinoma with wild-type TP53.
Annals of surgical oncology - 1 Dec 2013
Ishibashi Masahisa, Kogo Ryunosuke, Shibata Kohei, Ueo Hiroki, Uchi Ryutaro, Matsumura Tae, Takano Yuki, Sawada Genta, Takahashi Yusuke, Mima Kousuke, Kurashige Junji, Akiyoshi Sayuri, Iwaya Takeshi, Eguchi Hidetoshi, Sudo Tomoya, Sugimachi Keishi, Suzuki Akira, Wakabayashi Go, Mori Masaki, Mimori Koshi
Abstract excerpt
BACKGROUND: TP53 is one of the most widely known cancer suppressor genes. Mutations in TP53 are ubiquitously observed in almost all cancers. Incidences of mutations range from ~15-70 % in patients with hepatocellular carcinoma (HCC). Moreover, patients with mutated TP53 have poorer prognoses than those with wild-type TP53; therefore, it would be beneficial to predict the prognosis of HCC patients with wild-type...
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