Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Integrative Analysis of the Role of TP53 in Human Pan-Cancer

29 Nov 2023

Abstract excerpt

Tumor protein P53 (TP53) is an important tumor suppressor gene in humans. Under normal circumstances, TP53 can help repair mutated genes, or promote the death of cells with severe gene mutations (specifically, TP53 prevents cells from arrest in the G1/S phase when deoxyribonucleic acid (DNA) is damaged and promotes apoptosis if not repaired), and prevents normal cells from becoming malignant cells. TP53 mutations...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to Cancer-related Molecular Pathways
Share to RNA modifications and cancer

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38132447
DOI: 10.3390/cimb45120601

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integrative Analysis of the Role of TP53 in Human Pan-CancerPMID 38132447Read ↗

p53: from understanding its structure to advances in therapeutic targeting.Semantic proximity Read ↗

An overview of the functions of p53 and drugs acting either on wild- or mutant-type p53.Semantic proximity Read ↗

Comprehensive Bioinformatic Investigation of TP53 Dysregulation in Diverse Cancer LandscapesSemantic proximity Read ↗

Comprehensive omics studies of p53 mutants in human cancer.Semantic proximity Read ↗

TP53 mutations as potential prognostic markers for specific cancers: Analysis of data from The Cancer Genome Atlas and the International Agency for Research on Cancer TP53 DatabaseSemantic proximity Read ↗

Unraveling the Guardian: p53's Multifaceted Role in the DNA Damage Response and Tumor Treatment Strategies.Semantic proximity Read ↗

The TP53 tumor suppressor gene: From molecular biology to clinical investigationsSemantic proximity Read ↗

New insights into p53 functions through its target microRNAsSemantic proximity Read ↗

Recent Advances in p53Semantic proximity Read ↗

Potential therapeutic targets ofTP53gene in the context of its classically canonical functions and its latest non-canonical functions in human cancerSemantic proximity Read ↗

TP53: a key gene in human cancerSemantic proximity Read ↗

Advanced Strategies for Therapeutic Targeting of Wild-Type and Mutant p53 in Cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.