Article
Comprehensive characterization of genes associated with the TP53 signal transduction pathway in various tumors.
Molecular and cellular biochemistry - 1 Jul 2017
Ohnami Shumpei, Ohshima Keiichi, Nagashima Takeshi, Urakami Kenichi, Shimoda Yuji, Saito Junko, Naruoka Akane, Hatakeyama Keiichi, Mochizuki Tohru, Serizawa Masakuni, Ohnami Sumiko, Kusuhara Masatoshi, Yamaguchi Ken
Abstract excerpt
The TP53 signal transduction pathway is an attractive target for cancer treatments. In this study, we conducted a comprehensive molecular evaluation of 907 patients with cancer in Japan to identify genomic alterations in the TP53 pathway. TP53 mutations were frequently detected in many cancers, except melanoma, thymic tumors, gastrointestinal stromal tumors, and renal cancers. The frequencies of non-synonymous...
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