Article
HIV infection confers distinct mechanisms in severe drug eruption: Endogenous virus activation with aberrant Th2/Th1 and CD8+ T cells function.
Clinical and experimental pharmacology & physiology - 1 Jun 2020
Tang Jun-Ting, Li Yu-Ye, Zhang Yi, Liu Jun, Guan Wei, Wang Rui-Rui, He Li-Ping, Zhang Jian-Bo, Kuang Yi-Qun
Abstract excerpt
Severe drug eruption (SDE), a common skin disease, becomes dangerous when it occurs in patients with human immunodeficiency virus (HIV). However, the molecular mechanisms are poorly understood. Forty patients including HIV+ SDE+ (n = 15), HIV- SDE+ (n = 15) and HIV+ SDE- (n = 10) subjects were enrolled in our study. All HIV+ patients were at acquired immune deficiency syndrome (AIDS) stage. Serum levels of TNF-α,...
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