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Article

Mx1 reveals innate pathways to antiviral resistance and lethal influenza disease

21 Apr 2016

Abstract excerpt

Influenza A virus (IAV) causes up to half a million deaths worldwide annually, 90% of which occur in older adults. We show that IAV-infected monocytes from older humans have impaired antiviral interferon production but retain intact inflammasome responses. To understand the in vivo consequence, we used mice expressing a functional Mx gene encoding a major interferon-induced effector against IAV in humans. In...

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PMID: 27102485
DOI: 10.1126/science.aaf3926

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