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Article

AIM2 inflammasome is activated by pharmacological disruption of nuclear envelope integrity

26 Jul 2016

Abstract excerpt

Inflammasomes are critical sensors that convey cellular stress and pathogen presence to the immune system by activating inflammatory caspases and cytokines such as IL-1β. The nature of endogenous stress signals that activate inflammasomes remains unclear. Here we show that an inhibitor of the HIV aspartyl protease, Nelfinavir, triggers inflammasome formation and elicits an IL-1R-dependent inflammation in mice. We...

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PMID: 27462105
DOI: 10.1073/pnas.1602419113

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