Beyond microRNAs: Analysis of chimeric reads characterises the diverse targetome of AGO2-mediated regulation

Abstract excerpt

Argonaute proteins are instrumental in regulating RNA stability and translation. AGO2, the major mammalian Argonaute protein, is known to primarily associate with microRNAs, a family of small RNA ‘driver’ sequences, and identifies its targets primarily via a ‘seed’ mediated partial complementarity process Despite numerous studies, a definitive experimental dataset of AGO2 ‘driver’-’target’ interactions remains elu...

Topics

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• 3' Untranslated Regions
• Algorithms
• Binding Sites
• Mice
• MicroRNAs
• Polymorphism, Single Nucleotide
• Rats
• Software

Identifiers and source

Literature Corpus work

c973c0a3-c4e3-5cdf-bb98-b917ec73a995

DOI

10.1101/2023.08.24.554582