Article

Significance of druggable targets (PD-L1, KRAS, BRAF, PIK3CA, MSI, and HPV) on curatively resected esophageal squamous cell carcinoma

2020-09-18

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Esophageal squamous cell carcinoma (ESCC) still remains intractable disease with few therapeutic options. Programmed death-ligand 1 (PD-L1), which is essential for immune evasion, is involved in the pathogenesis of ESCC and thus is a potential therapeutic target. <italic>PIK3CA</italic>,<italic> KRAS</italic>,<italic> </italic>and <italic>BRAF </italic>mutations...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fce1eed2-5930-5f29-8d63-6ae8c511bc01
DOI: 10.21203/rs.3.rs-42266/v2

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Significance of druggable targets (PD-L1, KRAS, BRAF, PIK3CA, MSI, and HPV) on curatively resected esophageal squamous cell carcinomaDOI 10.21203/rs.3.rs-42266/v2Read

Significance of druggable targets (PD-L1, KRAS, BRAF, PIK3CA, MSI, and HPV) on curatively resected esophageal squamous cell carcinoma.Semantic proximity Read

Distinct genomic landscapes of gastroesophageal adenocarcinoma depending on PD-L1 expression identify mutations in RAS-MAPK pathway and TP53 as potential predictors of immunotherapy efficacy.Semantic proximity Read

Tumor immune microenvironment and immune checkpoint inhibitors in esophageal squamous cell carcinoma.Semantic proximity Read

Programmed death-1 ligand-1 gene rs2890658 polymorphism associated with the risk of esophageal squamous cell carcinoma in smokers.Semantic proximity Read

Clinicopathological characteristics and the relationship of PD-L1 status, tumor mutation burden, and microsatellite instability in patients with esophageal carcinomaSemantic proximity Read

Pathogenic and targetable genetic alterations in 70 urachal adenocarcinomas.Semantic proximity Read

Association of programmed death-1 polymorphisms with the risk and prognosis of esophageal squamous cell carcinoma.Semantic proximity Read

Genomic and transcriptomic insights into the precision treatment of pulmonary enteric adenocarcinoma.Semantic proximity Read

Analysis of Immunological Characteristics and Genomic Alterations in HPV-Positive Oropharyngeal Squamous Cell Carcinoma Based on PD-L1 Expression.Semantic proximity Read

Inhibition of Esophageal Squamous Cell Carcinoma Progression by MIR210HG and Activation of the P53 Signaling Pathway to Promote Apoptosis and AutophagySemantic proximity Read

KRAS gene mutation quantification in the resection or venous margins of pancreatic ductal adenocarcinoma is not predictive of disease recurrenceSemantic proximity Read

PD-L1 expression, tumor-infiltrating lymphocytes, mismatch repair deficiency, EGFR alteration and HPV infection in sinonasal squamous cell carcinoma.Semantic proximity Read