Article
Distinct genomic landscapes of gastroesophageal adenocarcinoma depending on PD-L1 expression identify mutations in RAS-MAPK pathway and TP53 as potential predictors of immunotherapy efficacy.
Annals of oncology : official journal of the European Society for Medical Oncology - 1 Jul 2021
Wang J Y, Xiu J, Baca Y, Arai H, Battaglin F, Kawanishi N, Soni S, Zhang W, Millstein J, Shields A F, Grothey A, Weinberg B A, Marshall J L, Lou E, Khushman M, Sohal D P S, Hall M J, Oberley M, Spetzler D, Shen L, Korn W M, Lenz H J
Abstract excerpt
BACKGROUND: The impact of molecular alterations on programmed death-ligand 1 (PD-L1) combined positive score (CPS) is not well studied in gastroesophageal adenocarcinomas (GEAs). We aimed to characterize genomic features of tumors with different CPSs in GEAs. PATIENTS AND METHODS: Genomic alterations of 2518 GEAs were compared in three groups (PD-L1 CPS ≥ 10, high; CPS = 1-9, intermediate; CPS < 1, low) using...
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