Article

Soluble MAC is primarily released from MAC-resistant bacteria that potently convert complement component C5

2021-12-15

Abstract excerpt

The Membrane Attack Complex (MAC or C5b-9) is an important effector of the immune system to kill invading microbes. MAC is formed when complement enzymes on the bacterial surface convert complement component C5 into C5b. Although the MAC is a membrane-inserted complex, soluble forms of MAC (sMAC, or terminal complement complex (TCC)) are often detected in sera of patients suffering from infections. Consequently, s...

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Literature Corpus work: bebb23b7-fc36-57e5-931f-f09dcff77f14
DOI: 10.1101/2021.12.15.472789

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