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Article

Neisseria meningitidis NalP cleaves human complement C3, facilitating degradation of C3b and survival in human serum.

Proceedings of the National Academy of Sciences of the United States of America - 7 Jan 2014

Del Tordello Elena, Vacca Irene, Ram Sanjay, Rappuoli Rino, Serruto Davide

Abstract excerpt

The complement system is a crucial component of the innate immune response against invading bacterial pathogens. The human pathogen Neisseria meningitidis (Nm) is known to possess several mechanisms to evade the complement system, including binding to complement inhibitors. In this study, we describe an additional mechanism used by Nm to evade the complement system and survive in human blood. Using an isogenic...

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Share to Complement C3
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24367091
DOI: 10.1073/pnas.1321556111
PMCID: PMC3890809

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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