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A long noncoding RNA, <i>LOC157273</i> , is the effector transcript at the chromosome 8p23.1- <i>PPP1R3B</i> metabolic traits and type 2 diabetes risk locus

2020-03-24

Abstract excerpt

<h4>Aims</h4> Causal transcripts at genomic loci associated with type 2 diabetes are mostly unknown. The chr8p23.1 variant rs4841132, associated with an insulin resistant diabetes risk phenotype, lies in the second exon of a long non-coding RNA (lncRNA) gene, LOC157273 , located 175 kilobases from PPP1R3B , which encodes a key protein regulating insulin-mediated hepatic glycogen storage in humans. We hypothesiz...

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Literature Corpus work
fccdfeb0-c344-5904-9bb4-b3162a0b8eba
DOI
10.1101/2020.03.24.000620
Open publication

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A long noncoding RNA, <i>LOC157273</i> , is the effector transcript at the chromosome 8p23.1- <i>PPP1R3B</i> metabolic traits and type 2 diabetes risk locusDOI 10.1101/2020.03.24.000620
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