Article
A Hepatocyte FOXN3-α Cell Glucagon Axis Regulates Fasting Glucose.
Cell reports - 10 Jul 2018
Karanth Santhosh, Adams J D, Serrano Maria de Los Angeles, Quittner-Strom Ezekiel B, Simcox Judith, Villanueva Claudio J, Ozcan Lale, Holland William L, Yost H Joseph, Vella Adrian, Schlegel Amnon
Abstract excerpt
The common genetic variation at rs8004664 in the FOXN3 gene is independently and significantly associated with fasting blood glucose, but not insulin, in non-diabetic humans. Recently, we reported that primary hepatocytes from rs8004664 hyperglycemia risk allele carriers have increased FOXN3 transcript and protein levels and liver-limited overexpression of human FOXN3, a transcriptional repressor that had not...
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