Protein Phosphatase 1 Regulatory Subunit 3B Genotype at rs4240624 Has a Major Effect on Gallbladder Bile Composition.

doi:10.1002/hep4.1630

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Protein Phosphatase 1 Regulatory Subunit 3B Genotype at rs4240624 Has a Major Effect on Gallbladder Bile Composition.

Hepatology communications - 1 Feb 2021

Männistö Ville, Kaminska Dorota, Käkelä Pirjo, Neuvonen Mikko, Niemi Mikko, Alvarez Marcus, Pajukanta Päivi, Romeo Stefano, Nieuwdorp Max, Groen Albert K, Pihlajamäki Jussi

Abstract excerpt

The protein phosphatase 1 regulatory subunit 3B (PPP1R3B) gene is a target of farnesoid X receptor (FXR), which is a major regulator of bile acid metabolism. Both PPP1R3B and FXR have been suggested to take part in glycogen metabolism, which may explain the association of PPP1R3B gene variants with altered hepatic computed tomography attenuation. We analyzed the effect of PPP1R3B rs4240624 variant on bile acid...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33553972
DOI: 10.1002/hep4.1630
PMCID: PMC7850313

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