Article
A Noncoding Variant Near PPP1R3B Promotes Liver Glycogen Storage and MetS, but Protects Against Myocardial Infarction.
The Journal of clinical endocrinology and metabolism - 23 Jan 2021
Kahali Bratati, Chen Yue, Feitosa Mary F, Bielak Lawrence F, O'Connell Jeffrey R, Musani Solomon K, Hegde Yash, Chen Yanhua, Stetson L C, Guo Xiuqing, Fu Yi-Ping, Smith Albert Vernon, Ryan Kathleen A, Eiriksdottir Gudny, Cohain Ariella T, Allison Matthew, Bakshi Andrew, Bowden Donald W, Budoff Matthew J, Carr J Jeffrey, Carskadon Shannon, Chen Yii-Der I, Correa Adolfo, Crudup Breland F, Du Xiaomeng, Harris Tamara B, Yang Jian, Kardia Sharon L R, Launer Lenore J, Liu Jiankang, Mosley Thomas H, Norris Jill M, Terry James G, Palanisamy Nallasivam, Schadt Eric E, O'Donnell Christopher J, Yerges-Armstrong Laura M, Rotter Jerome I, Wagenknecht Lynne E, Handelman Samuel K, Gudnason Vilmundur, Province Michael A, Peyser Patricia A, Halligan Brian, Palmer Nicholette D, Speliotes Elizabeth K
Abstract excerpt
CONTEXT: Glycogen storage diseases are rare. Increased glycogen in the liver results in increased attenuation. OBJECTIVE: Investigate the association and function of a noncoding region associated with liver attenuation but not histologic nonalcoholic fatty liver disease. DESIGN: Genetics of Obesity-associated Liver Disease Consortium. SETTING: Population-based. MAIN OUTCOME: Computed tomography measured liver...
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