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Retinoids rescue ceruloplasmin secretion and alleviate oxidative stress in Wilson’s disease-specific hepatocytes

2021-08-10

Abstract excerpt

<h4>Summary</h4> Wilson’s disease (WD) is a copper metabolic disorder, which is caused by defective ATP7B function. Here, we have generated induced pluripotent stem cells (iPSCs) from WD patients carrying compound heterozygous mutations on ATP7B . ATP7B loss- and gain-of-functions were further manifested with ATP7B-deficient iPSCs and heterozygously-corrected R778L WD patient-derived iPSCs using CRISPR-Cas9-base...

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Literature Corpus work
108f9b64-4395-5b06-9f71-2fe67327e4bd
DOI
10.1101/2021.08.10.455792
Open publication

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Retinoids rescue ceruloplasmin secretion and alleviate oxidative stress in Wilson’s disease-specific hepatocytesDOI 10.1101/2021.08.10.455792
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