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Article

MiR-16 regulates mouse peritoneal macrophage polarization and affects T-cell activation.

Journal of cellular and molecular medicine - 1 Oct 2016

Jia Xiaoqin, Li Xiaomin, Shen Yating, Miao Junjun, Liu Hao, Li Guoli, Wang Zhengbing

Abstract excerpt

MiR-16 is a tumour suppressor that is down-regulated in certain human cancers. However, little is known on its activity in other cell types. In this study, we examined the biological significance and underlying mechanisms of miR-16 on macrophage polarization and subsequent T-cell activation. Mouse peritoneal macrophages were isolated and induced to undergo either M1 polarization with 100 ng/ml of interferon-γ and...

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Source

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Identifiers

PMID: 27241533
DOI: 10.1111/jcmm.12882
PMCID: PMC5020626

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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