Article

Toward a Discipline of Pharmacoepigenomics.

2004-12-01

Abstract excerpt

This review argues that the epigenome, which plays a critical role in controlling gene expression, plays also an important role in drug responsiveness. The epigenome is composed of chromatin and its modifications and DNA methylation. DNA methylation and chromatin structure are dynamic and tightly linked. Alterations in DNA methylation are involved in the pathology of cancer and in normal aging. It is suggested her...

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Literature Corpus work: fc817b0d-d467-523f-b755-3e373a8535f1
DOI: 10.2174/1570160043377358

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