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Perspectives on Epigenetics and Its Relevance to Adverse Drug Reactions

20 Apr 2011

Abstract excerpt

Adverse drug reactions (ADRs) are a major problem in drug therapy and drug development. It can be anticipated that interindividual epigenetic differences that affect the expression of drug-metabolizing and disposition enzymes as well as of epigenetic effectors, such as pharmaceutical compounds, will have significant roles in determining an individual's susceptibility to ADRs. In this brief review, we provide an...

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PMID: 21508940
DOI: 10.1038/clpt.2011.21

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