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Article

Epigenetic Changes in Gene Expression for Drug‐Metabolizing Enzymes and Transporters

24 Oct 2013

Abstract excerpt

Individual differences in drug response can be caused by genetic and epigenetic variability and disease determinants. Pharmacoepigenetics is a new field that studies the expression changes in pharmacogenes without changes in DNA sequences. Epigenetic control mechanisms are associated with DNA methylation, histone modification, small noncoding RNAs, and nucleosome remodeling. Researchers are actively attempting to...

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PMID: 24166985
DOI: 10.1002/phar.1362

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