Pharmacoepigenomics: an interplay of epigenetic modulation of drug response and modulation of the epigenome by drugs.

Abstract excerpt

Epigenetic modulation captures the lack of correlation between the genotype and the phenotype. It also provides an interface between environment and the genotype leading to functional plasticity of the genome. While drug response can be modulated by the epigenome, the therapeutic intervention by drugs can also be considered as an environmental cue for epigenetic alterations. The effect of genetic polymorphism has...

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