Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A-SF3b complex.

doi:10.1038/ncomms15522

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Article

Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A-SF3b complex.

Nature communications - 25 May 2017

Teng Teng, Tsai Jennifer Hc, Puyang Xiaoling, Seiler Michael, Peng Shouyong, Prajapati Sudeep, Aird Daniel, Buonamici Silvia, Caleb Benjamin, Chan Betty, Corson Laura, Feala Jacob, Fekkes Peter, Gerard Baudouin, Karr Craig, Korpal Manav, Liu Xiang, T Lowe Jason, Mizui Yoshiharu, Palacino James, Park Eunice, Smith Peter G, Subramanian Vanitha, Wu Zhenhua Jeremy, Zou Jian, Yu Lihua, Chicas Agustin, Warmuth Markus, Larsen Nicholas, Zhu Ping

Abstract excerpt

Pladienolide, herboxidiene and spliceostatin have been identified as splicing modulators that target SF3B1 in the SF3b subcomplex. Here we report that PHF5A, another component of this subcomplex, is also targeted by these compounds. Mutations in PHF5A-Y36, SF3B1-K1071, SF3B1-R1074 and SF3B1-V1078 confer resistance to these modulators, suggesting a common interaction site. RNA-seq analysis reveals that PHF5A-Y36C...

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PMID: 28541300
DOI: 10.1038/ncomms15522
PMCID: PMC5458519

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