Article

The Mechanism and Energetics of the Dynein Priming Stroke

2023-06-11

Abstract excerpt

<h4>ABSTRACT</h4> Dyneins is an AAA+ motor responsible for motility and force generation towards the minus end of microtubules. Dynein motility is powered by nucleotide-dependent transitions of its linker domain, which transitions between straight (post-powerstroke) and bent (pre-powerstroke) conformations. To understand the dynamics and energetics of the linker, we per-formed all-atom molecular dynamics (MD) sim...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fc5b9f7e-e164-5cc6-bb27-8528fc57f5ad
DOI: 10.1101/2023.06.10.544469

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The Mechanism and Energetics of the Dynein Priming StrokeDOI 10.1101/2023.06.10.544469Read

Cryo-EM Reveals the Mechanochemical Cycle of Reactive Full-length Human Dynein-1Semantic proximity Read

Structural model for strain-dependent microtubule activation of Mg-ADP release from kinesin.Semantic proximity Read

Tension on the linker gates the ATP-dependent release of dynein from microtubules.Semantic proximity Read

A kinesin motor in a force-producing conformation.Semantic proximity Read

The structural switch of nucleotide-free kinesin.Semantic proximity Read

Allostery Wiring Map for Kinesin Energy Transduction and Its Evolution.Semantic proximity Read

Mapping the structural and dynamical features of kinesin motor domains.Semantic proximity Read

Thermodynamic properties of the kinesin neck-region docking to the catalytic core.Semantic proximity Read

A posttranslational modification of the mitotic kinesin Eg5 that enhances its mechanochemical coupling and alters its mitotic function.Semantic proximity Read

Human kinesin-5 KIF11 drives the helical motion of anti-parallel and parallel microtubules around each otherSemantic proximity Read

Direct observation of intermediate states during the stepping motion of kinesin-1.Semantic proximity Read

Kinesin motors as molecular machines.Semantic proximity Read