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Article

Tension on the linker gates the ATP-dependent release of dynein from microtubules.

Nature communications - 11 Aug 2014

Cleary Frank B, Dewitt Mark A, Bilyard Thomas, Htet Zaw Min, Belyy Vladislav, Chan Danna D, Chang Amy Y, Yildiz Ahmet

Abstract excerpt

Cytoplasmic dynein is a dimeric motor that transports intracellular cargoes towards the minus end of microtubules (MTs). In contrast to other processive motors, stepping of the dynein motor domains (heads) is not precisely coordinated. Therefore, the mechanism of dynein processivity remains unclear. Here, by engineering the mechanical and catalytic properties of the motor, we show that dynein processivity...

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Identifiers

PMID: 25109325
DOI: 10.1038/ncomms5587
PMCID: PMC4129465

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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