Article
A kinesin motor in a force-producing conformation.
BMC structural biology - 5 Jul 2010
Heuston Elisabeth, Bronner C Eric, Kull F Jon, Endow Sharyn A
Abstract excerpt
BACKGROUND: Kinesin motors hydrolyze ATP to produce force and move along microtubules, converting chemical energy into work by a mechanism that is only poorly understood. Key transitions and intermediate states in the process are still structurally uncharacterized, and remain outstanding questions in the field. Perturbing the motor by introducing point mutations could stabilize transitional or unstable states,...
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