Article
Mapping the structural and dynamical features of kinesin motor domains.
PLoS computational biology - 1 Jan 2013
Scarabelli Guido, Grant Barry J
Abstract excerpt
Kinesin motor proteins drive intracellular transport by coupling ATP hydrolysis to conformational changes that mediate directed movement along microtubules. Characterizing these distinct conformations and their interconversion mechanism is essential to determining an atomic-level model of kinesin action. Here we report a comprehensive principal component analysis of 114 experimental structures along with the...
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