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Article

Thermodynamic properties of the kinesin neck-region docking to the catalytic core.

Biophysical journal - 1 Mar 2003

Rice S, Cui Y, Sindelar C, Naber N, Matuska M, Vale R, Cooke R

Abstract excerpt

Kinesin motors move on microtubules by a mechanism that involves a large, ATP-triggered conformational change in which a mechanical element called the neck linker docks onto the catalytic core, making contacts with the core throughout its length. Here, we investigate the thermodynamic properties of this conformational change using electron paramagnetic resonance (EPR) spectroscopy. We placed spin probes at...

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Identifiers

PMID: 12609886
DOI: 10.1016/S0006-3495(03)74992-3
PMCID: PMC1302753

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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